Frequently Asked Questions

Mutant Genomics helps you turn supported DNA data into structured, educational health context. These answers explain what Mutant does, how it handles your data, how to interpret the results, and how free and paid access work.

About Mutant

What is Mutant Genomics?

Mutant is an educational genetic-analysis platform. It organizes selected genetic variants into biological modules, systems, and focused hubs; identifies converging patterns; and surfaces ranked health hypotheses with the supporting evidence, coverage, and limitations.

Mutant is designed to help you explore how inherited tendencies may fit into a broader health picture. It does not diagnose disease or determine the cause of a medical problem.

What is the goal of Mutant?

The goal is to make genetic information more useful without overstating what DNA can show.

Mutant helps you move beyond isolated variants and long lists of traits by organizing related findings into a biological model. That model can help you identify questions worth exploring alongside symptoms, laboratory results, medical records, medications, health history, and professional medical guidance.

How is Mutant different from a typical consumer DNA report?

Many consumer reports explain one variant or trait at a time. Mutant evaluates how multiple genetic signals relate across biological processes.

It groups relevant variants into weighted modules, maps those modules into systems and hubs, looks for converging patterns, and uses that structure to rank educational health hypotheses. Each result retains its supporting evidence, genetic coverage, and important limitations.

Who is Mutant designed for?

Mutant is designed for people who want to:

• Learn more from DNA data they already have
• Explore complex or interconnected health questions
• Understand how genetic findings may relate across biological systems
• Bring organized genetic context into conversations with AI tools or healthcare professionals
• Review the evidence and limitations behind genetic interpretations

No genetics background is required.

Understanding Your Analysis

What are biological modules?

Biological modules are focused groups of related genetic signals. A module may represent a process involving signaling, transport, enzyme activity, metabolism, immune regulation, nutrient handling, or cellular response.

Modules help Mutant evaluate related variants together instead of treating every SNP as an independent conclusion.

What are systems and hubs?

Systems provide the broadest organizational view of your results. Hubs divide each system into more focused areas that are easier to explore.

Mutant organizes findings into the following systems and focused hubs:

These are organizational views of your genetic findings. A hub is not a diagnosis, and related findings may overlap across systems.

What are converging patterns?

A converging pattern appears when multiple weighted biological modules point toward an overlapping biological theme.

This is different from finding a single variant associated with a trait. Convergence shows that several pieces of genetic evidence support a related question. It does not prove that the process is impaired or that it is causing symptoms.

What are ranked health hypotheses?

Ranked health hypotheses are biologically plausible interpretations that Mutant surfaces for further exploration.

The ranking reflects the available genetic evidence within your analysis, including relevant modules, converging patterns, individual genetic signals, evidence quality, and coverage.

A higher rank indicates greater priority for exploration within your analysis. It is not a probability that a condition is present and does not confirm a hypothesis or identify a disease.

Are health hypotheses the same as diagnoses or root causes?

No. A hypothesis is an educational starting point.

Genetics can suggest susceptibility or a biological tendency, but it usually cannot establish what is happening in your body now or explain a health problem by itself. Laboratory results, medical history, symptoms, environment, medications, and other factors may support, challenge, or change the relevance of a hypothesis.

Mutant therefore uses language such as may, could, and is associated with rather than claiming to have discovered a diagnosis or root cause.

Why do some hypothesis or module names sound unfamiliar?

Some findings map closely to familiar clinical concepts. Others describe a narrower biological pattern that does not have a widely used everyday name.

Mutant uses descriptive labels to make those patterns easier to explore. A label is not the name of a new disease, and it should not be interpreted as a medical diagnosis.

Can one important variant influence a result?

Yes. Many findings depend on the combined influence of several variants, but some clinical or inherited-health findings may be influenced more strongly by a particular high-impact variant.

Mutant shows the supporting signals so you can distinguish a broadly convergent pattern from a result that depends more heavily on one finding. Selected Clinical & Inherited Health findings require variant confirmation and interpretation alongside relevant laboratory results, medical history, and family history.

What is Evo 2?

Evo 2 is a DNA sequence model developed by Arc Institute. It learns patterns in DNA sequences rather than in variant-by-variant association data.

Mutant uses Evo 2 as a weighting step inside its existing scoring. It is not a separate evidence source, a diagnosis, or a disease-risk percentage.

How does Mutant use it?

Mutant uses the precomputed Evo 2 score for a catalog variant to adjust the weight that variant already carries in your analysis: catalog variant → precomputed Evo 2 score → adjusted SNP weight → module or matched storm score.

Evo 2 adjusts existing SNP weights. It does not add a separate evidence score, and it does not change whether a multi-variant pattern is reported as matched.

Does a 1.31 multiplier mean 31% higher disease risk?

No. The multiplier is a weighting factor applied to an existing SNP weight in Mutant’s scoring. It is not a disease-risk percentage and does not mean a 31% higher chance of any condition.

A difference in model likelihood is not a measure of clinical harm. It describes DNA sequence context, not your personal risk.

Is my uploaded DNA sent to Evo 2 for this feature?

No. This feature uses Evo 2 scores that Mutant precomputes for the variants in its catalog. Your uploaded DNA is not sent to Evo 2 for this feature.

What happens when a variant has no Evo 2 score?

A variant without a usable Evo 2 score keeps its original weight. Mutant does not treat a missing Evo 2 score as a normal or protective result.

Why can my results or rankings change?

Results may change when:

• You provide a DNA file with broader coverage
• Mutant adds or refines supported variants, modules, hubs, or hypotheses
• New research changes the strength or interpretation of existing evidence

Updates do not change your DNA. They change the amount of information available or how that information is organized and evaluated.

DNA Files, Coverage, and Privacy

What DNA files can Mutant analyze?

Mutant currently supports:

• Raw DNA .txt files from 23andMe
• Raw DNA .txt files from AncestryDNA
• Supported whole-genome .vcf or .vcf.gz files, including supported SNP and insertion/deletion data

If your provider supplies SNPs and insertions/deletions separately, you can select both files. Coverage varies by provider, testing platform, file version, and format.

What is the difference between microarray and whole-genome data?

23andMe and AncestryDNA use microarrays that test a selected set of variants. These files can provide useful coverage for many common genetic signals but do not include every variant.

Whole-genome sequencing generally provides broader coverage, including more rare and less commonly tested variants. Broader coverage can improve the resolution of some modules and hypotheses, but it does not remove the uncertainty inherent in genetic interpretation.

Can I start with a microarray file and add whole-genome data later?

Yes. You can begin with supported data you already have and add supported whole-genome data later. Mutant can update the analysis using the additional coverage.

What does DNA coverage mean?

Coverage indicates how much of the genetic data needed for a particular analysis was available in your file.

Lower coverage means Mutant had fewer relevant variants to evaluate. Missing data is not treated as a normal or protective result, and coverage should always be considered when interpreting a finding.

Is my full DNA file uploaded to Mutant?

Mutant normally processes supported raw DNA files locally in your browser and uploads the selected genetic variants needed to create your analysis. Those variants and the resulting analysis are saved with your account.

The current upload flow can upload your full DNA file if your browser cannot process it locally, or if a whole-genome file yields no matching variants. Local processing therefore does not apply to every upload.

Does Mutant sell my genetic data?

No. Mutant does not sell your genetic data.

For more information about storage, account controls, service providers, and data handling, review the Privacy Policy and Data Policy.

Health Context and AI

How do I use Mutant with ChatGPT?

If you use Mutant in ChatGPT, connect your Mutant account and approve the permissions for that connection during setup. Mutant can then return relevant findings when you ask about them, within your account's Free or Full access. No export is required.

Mutant supplies the genetic findings requested through the plugin. It does not automatically receive your complete ChatGPT conversation, medical records, or connected health information.

What permissions do I review when connecting Mutant to ChatGPT?

The ChatGPT connection asks you to approve genetic-data processing and the sharing of relevant Mutant results with ChatGPT. That permission screen is specific to the ChatGPT connection.

You can disconnect Mutant from the ChatGPT connection permissions screen. This stops future access through that connection; it does not remove findings already shared in a conversation.

Can I use Mutant with an AI tool other than ChatGPT?

Yes. Select Export for AI to download a structured, portable Health Context.

You can provide that file to another compatible AI tool and combine it with laboratory results, records, medications, symptoms, or other health information you choose to share there.

Does Mutant or AI analyze my medical records?

Mutant builds your analysis from your genetic data. You bring symptoms, laboratory results, medications, and medical records into an AI conversation or a discussion with a qualified healthcare professional to explore how they relate to your genetic findings.

When you use the ChatGPT plugin, ChatGPT can explore Mutant findings alongside health information available in your conversation. When you use an export with another AI tool, that tool can work with the information you choose to provide to it. The AI service's own privacy terms and data controls apply to information used there.

Can I trust an AI-generated health interpretation?

AI can be helpful for organizing information, identifying questions, and comparing a genetic hypothesis with other health context. It can also misunderstand evidence, omit important details, or generate incorrect conclusions.

Review AI-generated interpretations critically. Do not use them as a substitute for medical evaluation, diagnosis, or treatment.

Evidence and Medical Limitations

How does Mutant evaluate evidence?

Mutant considers factors such as research quality, biological relevance, supporting genetic signals, effect direction, and available genetic coverage. Results include evidence and limitation information so users can see why a finding was surfaced and how cautiously it should be interpreted.

Not every association has the same strength, and published research may change over time.

Does genetic susceptibility mean I will develop a condition?

No. Genetic susceptibility is not certainty.

Most health outcomes reflect a combination of genetics, age, environment, behavior, exposures, medical history, and chance. A genetic association may slightly alter probability without determining an outcome.

Does Mutant diagnose medical conditions?

No. Mutant does not diagnose, treat, cure, or prevent disease.

It provides educational genetic analysis that may help you organize questions and prepare for more informed discussions. A Mutant result should not be used to start, stop, or change medication, supplementation, testing, or treatment without appropriate professional guidance.

Is Mutant medical advice?

No. Mutant is for educational and informational purposes only and does not replace professional medical care.

Contact a qualified healthcare professional about symptoms, abnormal laboratory results, possible inherited conditions, or medical decisions. Seek urgent medical care for urgent or severe symptoms.

Access and Pricing

Is Mutant free?

Mutant Free includes your top three ranked health hypotheses in full, their evidence breakdowns, and the related findings available within your Free access. A credit card is not required to create a free account.

Free access is an ongoing part of the product model.

What is included with full access?

Mutant Full unlocks all ranked health hypotheses in your analysis, their full evidence breakdowns, contributing patterns, and supporting variants for $49/year, billed annually.

See Free and Full access details to compare what is included before upgrading.

Do I need full access to use the ChatGPT plugin?

Mutant Free includes exploration of your included findings through Mutant in ChatGPT. Mutant Full unlocks the additional hypotheses and evidence associated with your account. A request in ChatGPT does not automatically purchase an upgrade.

Can I delete my DNA data or close my account?

After signing in, account controls let you clear a report's DNA data and derived analysis or request account closure to delete your Mutant-stored data.

Deletion does not remove copies you already exported or shared with another service, such as a ChatGPT conversation. Read the Privacy Policy and Data Policy for details.

Where should I start?

Create a free account and upload a supported DNA file. After your file is processed, you can review the available analysis in Mutant or access your findings through the Mutant ChatGPT plugin.

You can also explore the interactive sample analysis before creating an account.

Mutant Genomics is for educational and informational purposes only. It does not provide medical advice, diagnosis, or treatment. Always consult a qualified healthcare professional about medical concerns and decisions.